A truncated H-NS-like protein from enteropathogenic Escherichia coli acts as an H-NS antagonist
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چکیده
منابع مشابه
Nucleotide sequence of a newly-identified Escherichia coli gene, stpA, encoding an H-NS-like protein.
analysis of a 978-bp fragment of this segment revealed an ORF , w . r o , * r. A A , ^ c ,,noo> ^ * o i«> M.-> , J , r . b r IIA • J /i-.N 1Martinez,E., Bartolomi.B. and de la Cruz,F. (1988) Gene 68, 159-162. that encodes a putative protein of 134 ammo acids (Figure 1). 2 DevereuxJ., Haeberli.P. and Smithies.O. (1984) Nucleic Acids Res. 12, Comparative searches (FASTA, TFASTA (2)) showed that t...
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The lysU gene encoding lysyl-tRNA synthetase of Escherichia coli is normally silent at low temperatures and is expressed by certain metabolites and stimuli. A novel class of lysU-constitutive mutations were isolated by random insertion mutagenesis. These mutations nullified the hns gene encoding a histone-like protein, H-NS, and affected thermoregulation of lysU.
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Enterohemorrhagic Escherichia coli (EHEC) is a Shiga-toxigenic pathogen capable of inducing severe forms of enteritis (e.g., hemorrhagic colitis) and extraintestinal sequelae (e.g., hemolytic-uremic syndrome). The molecular basis of colonization of human and animal hosts by EHEC is not yet completely understood, and an improved understanding of EHEC mucosal adherence may lead to the development...
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The histone-like protein H-NS is a major component of the bacterial nucleoid and plays a crucial role in global gene regulation of enteric bacteria. It is known that the expression of a variety of genes is repressed by H-NS, and mutations in hns result in various phenotypes, but the role of H-NS in the drug resistance of Escherichia coli has not been known. Here we present data showing that H-N...
متن کاملEscherichia coli histone-like protein H-NS preferentially binds to horizontally acquired DNA in association with RNA polymerase.
Heat-stable nucleoid-structuring protein (H-NS) is one of the main nucleoid proteins expressed in exponentially growing Escherichia coli cells. In addition to a role in nucleoid organization, H-NS functions as a pleiotropic regulator of gene expression. The genome-wide distribution of H-NS, compared with the distribution of RNA polymerase and transcriptionally active genes, was investigated usi...
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ژورنال
عنوان ژورنال: Molecular Microbiology
سال: 2005
ISSN: 0950-382X,1365-2958
DOI: 10.1111/j.1365-2958.2005.04569.x